Postoperative analgesia
Conditions
Interventions
Oliceridine group:Patients in the oliceriding group will receive oliceridine 1.5mg analgesic treatment after operation
oliceridine 0.5mg should be given for analgesic relief during PACU stay time
Morphine gruop:Patients in the morphine group will receive morphine 4mg analgesic treatment after operation
morphine 1mg should be given for analgesic relief during PACU stay time
Sponsors
The Second Affiliated Hospital of Kunming Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. Patients who undergo elective thoracoscopic surgery; 2. Age 18-75 years old; 3. ASAI.-III; 4. BMI 18.5-30kg/m^2.
Exclusion criteria
Exclusion criteria: 1. Preoperative respiratory failure; 2. Advanced tumors with extensive metastasis or need to receive other adjuvant therapy; 3. Suffering from respiratory sleep apnea syndrome; 4. Hepatic or renal insufficiency; 5. Long-term use of sleeping pills; 6. Long-term hormone therapy; 7. Suffering from mental illness; 8. Lactation; 9. Chronic pain before surgery; 10. Hypersensitivity to the investigational drugs.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Extubation time; | — |
Secondary
| Measure | Time frame |
|---|---|
| Modified alertness-sedation score during the PACU stay;NRS score;The numbers of analgesic remedies during PACU stay;PACU stay time;Postoperative adverse reactions;QoR-15 of 24 hours after surgery;Time to first ambulation (hours from surgery end);Time to first oral intake (hours from surgery end);Adverse reactions during PACU stay; | — |
Countries
China
Contacts
Public ContactChen Ying
The Second Affiliated Hospital of Kunming Medical University
Outcome results
None listed