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The application of amide proton transfer (APT) in magnetic resonance (MR) simulation for glioma radiotherapy and prediction of recurrence patterns

The application of amide proton transfer (APT) in magnetic resonance (MR) simulation for glioma radiotherapy and prediction of recurrence patterns

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR2500096712
Enrollment
Unknown
Registered
2025-02-05
Start date
2025-02-11
Completion date
Unknown
Last updated
2025-02-10

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

glioma

Interventions

Case Group:None

Sponsors

Sun Yat-sen University Cancer Center
Lead Sponsor

Eligibility

Sex/Gender
All
Age
1 Years to 80 Years

Inclusion criteria

Inclusion criteria: 1.Confirmed by histology or cytology as intracranial WHO grade 2-4 glioma , and after surgery (including biopsy, partial resection, total resection); 2.Expected survival period exceeds 3 months; 3.No history of cranial radiation therapy; 4.Sign informed consent form;

Exclusion criteria

Exclusion criteria: 1.Existence of meningeal or spinal cord metastasis; 2.Contraindications for MR, such as metal implantation, contrast agent allergy, etc; 3.Unable to cooperate with radiotherapy, such as claustrophobia, etc; 4.Refusal to use standard chemotherapy regimen (temozolomide) for high-grade gliomas;

Design outcomes

Primary

MeasureTime frame
PFS;failure pattern;—

Secondary

MeasureTime frame
ORR;OS;neurocognitive function;—

Countries

China

Contacts

Public ContactXiaojing Du

Sun Yat-sen University Cancer Center

duxj@sysucc.org.cn+86 20 87343501

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026