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To investigate the bacterial genomics of Helicobacter pylori (H. pylori) in patients with refailure of eradication therapy under the guidance of antibiotic susceptibility

To investigate the bacterial genomics of Helicobacter pylori (H. pylori) in patients with refailure of eradication therapy under the guidance of antibiotic susceptibility

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR2500096705
Enrollment
Unknown
Registered
2025-02-05
Start date
2025-02-06
Completion date
Unknown
Last updated
2025-02-10

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None

Interventions

Observation group:None

Sponsors

The First Affiliated Hospital of Nanjing Medical University
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 70 Years

Inclusion criteria

Inclusion criteria: (1) Aged between 18 and 70 years. (2) Patients with Helicobacter pylori eradication failure, guided by antibiotic susceptibility testing. (3) Positive result in the ^13C urea breath test. (4) Voluntarily participating in this clinical trial, providing informed consent, and signing the informed consent form.

Exclusion criteria

Exclusion criteria: (1) Received H. pylori treatment or related therapies in the past four weeks. (2) Taken any of the following medications within one month prior to specimen collection: antibiotics, probiotics, acid-suppressive drugs, or antimicrobial traditional Chinese medicine. (3) Taking anticoagulant medications and unable to undergo gastric mucosal biopsy. (4) Suffering from severe primary conditions such as heart, liver, kidney, lung, hematologic, or neurological diseases. (5) Unable to tolerate painless gastroscopy. (6) Pregnant or breastfeeding women. (7) Patients deemed unsuitable for participation by the investigator.

Design outcomes

Primary

MeasureTime frame
Helicobacter pylori Genome;

Countries

China

Contacts

Public ContactFeng Ye

The First Affiliated Hospital of Nanjing Medical University

fengye@njmu.edu.cn+86 138 1589 7873

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026