Emergence Agitation after general anesthesia and postoperative cognitive dysfunction.
Conditions
Interventions
Group S:Continuously pump the same volume of physiological saline as Group R
Group R:Continuous pumping of remifentanil 0.1µg /( kg·min)
Sponsors
The First Affiliated Hospital, College of Medicine, Zhejiang University
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. Patients undergoing elective intracranial surgery under general anesthesia in neurosurgery; 2. Operation time 2–6 h with emergence in the PACU; 3. 18 years old <= age <= 75 years old; 4. ASA Level I-II;
Exclusion criteria
Exclusion criteria: 1. Unable to communicate normally before surgery; 2. Subjects with mental illness, long-term use of psychotropic drugs; 3. History of central nervous system diseases (such as dementia, Parkinson's disease, and cerebral infarction); 4. History of opioid allergy and addiction to abuse; 5. Allergic to propofol; 6. Severe cardiopulmonary dysfunction;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The incidence of emergence agitation; | — |
Secondary
| Measure | Time frame |
|---|---|
| Time to regain consciousness, time to extubation and total PACU duration;Extubation comfort;Awakening quality;Adverse events including desaturation bradycardia , hypotension, nausea and vomiting;heart rate;Pain intensity;Postoperative delirium; | — |
Countries
China
Contacts
Public ContactYao Yong-Xing
The First Affiliated Hospital, College of Medicine, Zhejiang University
Outcome results
None listed