Cognitive impairment
Conditions
Interventions
Chronic pain group:Group by: Patients with knee or hip surgery with a VAS score of >=4 (grade III or IV) and a duration of >=6 weeks
control group:Group by: Patients with knee or hip surgery with a VAS score of <3
Sponsors
Anhui Public Health Clinical Center
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Age between 18-60 years old; 2. Able to understand the research objectives and sign informed consent forms; 3. Knee or hip joint surgery needs to be performed under combined spinal and epidural anesthesia; 4. Able to communicate well with researchers and comply with the entire experimental requirements.
Exclusion criteria
Exclusion criteria: 1. There are contraindications related to epidural anesthesia; 2. Previous comorbidities of internal medicine such as coronary heart disease and severe cerebrovascular disease; 3. Combine pain in areas other than joint pain, such as headaches, lower back pain, etc; 4. There are contraindications for magnetic resonance imaging (such as non magnetic compatible metal implants, claustrophobia, etc.); 5. History of alcohol abuse (alcohol consumption >= 1000 g /day); 6. History of previous head trauma; 7. Education level below primary school; 8. Female patients are in the perinatal period; 9. Communication barriers or inability to cooperate; 10. Recently participated in other clinical trials.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| MoCA rating;Anxiety self-rating scale score;Self-Rating Depression Scale;Head magnetic resonance imaging;CX3CL1;IL-6; | — |
Countries
China
Contacts
Public ContactWeiwei Wu
Anhui Public Health Clinical Center
Outcome results
None listed