Acute lung injury
Conditions
Interventions
Experimental group:Adjust the inspiratory to expiratory ratios (1:2, 1:1.5, 1:1, 1.5:1, 2:1) in sequence using a randomized order
Sponsors
The First Medical Center of the PLA General Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. ASA grade I-II 2. Age 18-65 years 3.18kg/m2<=BMI<=35kg/m^2;
Exclusion criteria
Exclusion criteria: 1.Patients who refuse to participate in the study or do not sign the informed consent form; 2.Patients who have had symptoms of upper respiratory tract infection or pulmonary infection within the past 4 weeks, with chest X-ray indicating pneumonia; 3.Patients with diseases that affect thoracic and pulmonary compliance, such as pectus carinatum, pectus excavatum, history of chest trauma or surgery, chronic obstructive pulmonary disease (COPD), bullous lung disease, pleural effusion, and acute respiratory distress syndrome (ARDS); 4.Patients with a history of neuromuscular dysfunction; 5.Patients with severe cardiovascular events, pulmonary, renal, or hematologic diseases; 6.Patients who have received general anesthesia within 7 days prior to enrollment; 7.Patients with psychiatric disorders or cognitive impairments; patients with a history of abuse of psychotropic drugs or anesthetic agents. 8.Other conditions deemed by the investigator as unsuitable for participation in the clinical trial
Design outcomes
Secondary
| Measure | Time frame |
|---|---|
| Driving pressure;Lung Compliance;Mean airway pressure; | — |
Primary
| Measure | Time frame |
|---|---|
| Mechanical power; | — |
Countries
China
Contacts
Public ContactZhang Changsheng
The First Medical Center of the PLA General Hospital
Outcome results
None listed