Knee diseases
Conditions
Interventions
Liposomal Bupivacaine group:use Liposomal Bupivacaine to perform Adductor Canal Block Combined with iPACK Block
Ropivacaine group:use Ropivacaine to perform Adductor Canal Block Combined with iPACK Block
Sponsors
Shanghai East Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1.Age < 80 years; 2.Scheduled for unilateral TKA for the first time; 3.The American Society of Anesthesiologists (ASA) Physical Status I-III.
Exclusion criteria
Exclusion criteria: (1) Patients undergoing emergency surgery; (2) Those with hypertension, diabetes, etc. and uncontrolled; (3) History of neurological diseases such as stroke and epilepsy; (4) Combined with severe liver and kidney damage, heart failure, malignant tumors, etc.; (5) Long-term use of analgesic drugs; (6) Infection at the puncture site; (7) Mental illness that cannot cooperate with the study; (8) Those who are allergic to the drugs used in the study; (9) Patients who are pregnant, breastfeeding or trying to become pregnant; (10) Diabetic neuropathy, coagulation or bleeding disorders, severe peripheral vascular diseases, etc.; (11) Has participated in other clinical trials.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Visual analog scale; | — |
Secondary
| Measure | Time frame |
|---|---|
| The first time the analgesic pump is pressed and the total number of presses within 48 hours;First use time, total dosage, and salvage analgesia rate of opioid drugs (hydrocodone);Total consumption of opioid drugs;Time of first straight leg elevation;Postoperative hospitalization time;Intraoperative changes in mean arterial pressure and heart rate;Remedial analgesia rate; | — |
Countries
China
Contacts
Public ContactShen Wang
Shanghai East Hospital
Outcome results
None listed