Perioperative neurocognitive disorders, PND
Conditions
Interventions
Experimental Group (Dexmedetomidine Group):Anesthesia induction: Dexmedetomidine was pumped at a loading of 0.5ug/kg for 10 minutes before induction, followed by intravenous dexamethasone 5mg, butorph
Control Group (Conventional Regimen Group):Anesthesia induction: intravenous dexamethasone 5 mg, butorphanol 15ug/kg, sufentanil 0.2-0.5ug/kg, and propofol 1-2.5mg/kg until the patient loses conscious
Sponsors
Zhongda Hospital, Southeast University
Eligibility
Sex/Gender
All
Age
65 Years to No maximum
Inclusion criteria
Inclusion criteria: 1.Age>=65 years old; 2.ASA grade I~III; 3.Patients undergoing tertiary or quaternary orthopaedic general anesthesia surgery.
Exclusion criteria
Exclusion criteria: 1.Parkinson's disease, Alzheimer's disease, depression and other mental diseases existed before surgery; 2.Dependence on alcohol, psychotropic drugs or long-term use of antipsychotic drugs; 3.Blindness, deafness, language impairment, inability to speak Chinese, or other communication difficulties; 4.Renal failure requiring dialysis (serum creatinine >707umol/L or glomerular filtration rate ml/min),and acute kidney injury with serum creatinine >=442umol/L or daily increase >177umol/L; 5.Abnormal liver function with Child-Pugh grading score >=8; 6.Patients with contraindications to dexmedetomidine: patients with allergy to dexmedetomidine and its components, and patients with severe heart block; 7.Preoperative planned/unplanned transfer to ICU; 8.Serious brain diseases such as large-scale cerebral infarction, cerebral hemorrhage, brain trauma, etc.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Intraoperative sleep spindle related indicators; | — |
Secondary
| Measure | Time frame |
|---|---|
| Incidence of POD;Sleep disturbance score;Postoperative pain score; | — |
Countries
China
Contacts
Public ContactQiu Xiaodong
Zhongda Hospital, Southeast University
Outcome results
None listed