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PLA2G2A-mediated ferroptosis on dendritic cell in sepsis

PLA2G2A-mediated ferroptosis on dendritic cell in sepsis

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR2500096624
Enrollment
Unknown
Registered
2025-01-27
Start date
2025-02-01
Completion date
Unknown
Last updated
2025-02-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Sepsis

Interventions

Sponsors

Central Hospital of Dalian University of Technology(Dalian Municipal Central Hospital)
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 60 Years

Inclusion criteria

Inclusion criteria: ? Newly admitted patients with sepsis within 1 day in ICU; (2) Unresponsive to fluid therapy, with a serum lactate level greater than 2 mmol /L and requiring vasopressors to maintain a mean arterial pressure greater than or equal to 65mmHg; ? Investigator age: > 18 years old and < 60 years old.

Exclusion criteria

Exclusion criteria: ? Combined with other autoimmune diseases; ? Serious primary diseases of cardiovascular, cerebrovascular, liver, kidney and hematopoietic system; ? Pregnant or lactating women; ? History of malignant tumor; ? Steroid and immunosuppressant therapy in the past 3 months; ? Organ transplantation less than 1 year; ? Receiving cytokine clearance drug or adsorber treatment; ? Severe thrombocytopenia (<30.000/µL platelet count); ? Were included in other ICU studies.

Design outcomes

Primary

MeasureTime frame
PLA2G2A;

Countries

China

Contacts

Public ContactHong Zhu

Central Hospital of Dalian University of Technology(Dalian Municipal Central Hospital)

zhuhong851203@sina.com+86 411 8441 2001

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026