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To study the effect of low opioid anesthesia on the immune system of patients with lung cancer after operation

To study the effect of low opioid anesthesia on the immune system of patients with lung cancer after operation

Status
Recruiting
Phases
Phase 4
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2500096617
Enrollment
Unknown
Registered
2025-01-26
Start date
2024-01-11
Completion date
Unknown
Last updated
2025-02-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

lung cancer

Interventions

OSA group:Opioid-sparing anesthesia
OA group:Normal opioid anesthesia

Sponsors

The Second Affiliated Hospital of Dalian Medical University
Lead Sponsor

Eligibility

Sex/Gender
All
Age
40 Years to 60 Years

Inclusion criteria

Inclusion criteria: Age range: 40-60 years old, ASA (American Society of Anesthesiologists) grades I-III, ?Body Mass Index (BMI) of 18.5-28.0, underwent thoracoscopic lobectomy, all surgeries were performed using a lateral incision on the chest wall with unilateral insertion of a drainage tube.

Exclusion criteria

Exclusion criteria: Has a serious history of heart, liver, kidney and other diseases; History of allergy to anesthetic drugs; Surgical site infection; Neurological disorders or mental illnesses; Pregnancy or breastfeeding; Emergency surgery; Intracranial surgery; Transplant surgery or transplant patients; Planned regional anesthesia surgery; Atrioventricular, intraventricular, or sinoatrial conduction block; Patients who have been taking receptor blockers for a long time and have a heart rate below 50 beats per minute; Cardiac dysfunction with a left ventricular ejection fraction below 40%; Epilepsy or epileptic seizures; Physiology of acute encephalopathy; Patients with preoperative pulse oximetry (Spo2) less than 95%; Severe liver dysfunction (prothrombin ratio less than 15%).

Design outcomes

Primary

MeasureTime frame
Neutrophil-to-Lymphocyte Ratio;

Secondary

MeasureTime frame
blood pressure;heart rate;Patient recovery time;

Countries

China

Contacts

Public ContactZhou Feng

The Second Affiliated Hospital of Dalian Medical University

zhou6dl@163.com+86 139 4263 8716

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026