Sepsis-associated encephalopathy
Conditions
Interventions
The sepsis-associated encephalopathy group and the non-sepsis-associated encephalopathy group:None
Sponsors
The First Affiliated Hospital of Kunming Medical University
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Patients with sepsis who met the diagnostic criteria of sepsis 3.0 ; 2. Sepsis-associated encephalopathy was defined as brain dysfunction in the presence of sepsis and without any exclusion criteria. Patients were evaluated using the Confusion Assessment Method for the ICU (CAM-ICU), Glasgow Coma Scale (GCS), and Richmond Agitation-Sedation Scale (RASS). Those with a positive CAM-ICU were classified as the SAE group, and those with a negative CAM-ICU were classified as the Non-SAE group; 3. Age >= 18 years old.
Exclusion criteria
Exclusion criteria: 1. Those with incomplete clinical data or non-cooperation; 2. Those with abnormal thyroid hormone secretion disorders (such as hypothyroidism, hyperthyroidism, hyperfunctional thyroid adenoma, etc.); 3. Those with a previous history of hypothalamic-pituitary diseases; 4. Those with a previous history of adrenal diseases; 5. Those with a previous history of autoimmune diseases; 6. Those with hematological disorders or patients with advanced-stage tumors; 7. Those with long-term abnormal lipid status, long-term use of lipid-regulating drugs, glucocorticoids, immunosuppressants, or those who have received parenteral lipid nutrition before enrollment; 8. Those in a terminal state upon admission to the ICU, those who were automatically discharged or gave up treatment within 24 hours of ICU admission, or those with severe liver and kidney dysfunction; 9. Pregnant and lactating women; 10. Those with any existing or current central nervous system disorders, including head trauma, stroke, epilepsy, intracranial infection, Alzheimer's disease, hepatic encephalopathy, pulmonary encephalopathy, severe electrolyte imbalance, and cardiac arrest, etc.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| High-density lipoprotein cholesterol; | — |
Secondary
| Measure | Time frame |
|---|---|
| Mortality in 28 days; | — |
Countries
China
Contacts
Public ContactPengxi Zhu
The First Affiliated Hospital of Kunming Medical University
Outcome results
None listed