Correlation between perioperative brain cell insulin resistance and postoperative cognitive dysfunction in patients with valvular heart disease

Status

Recruiting

Phases

Early Phase 1

Study type

Observational

Source

ChiCTR

Registry ID

ChiCTR2500096606

Enrollment

Unknown

Registered

2025-01-26

Start date

2023-11-01

Completion date

Unknown

Last updated

2025-02-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

valvular heart disease

Interventions

Patients undergoing cardiac valve replacement under cardiopulmonary bypass:Nil

Eligibility

Sex/Gender

All

Age

18 Years to 90 Years

Inclusion criteria

Inclusion criteria: 1. Patients >=18 years old; 2. The patients voluntarily joined the trial; 3. Preoperative MMSE score of patients was >=24 points

Exclusion criteria

Exclusion criteria: 1. Second operation; 2. Diabetic patients; 3. Patients with abnormal liver and kidney function; 4. Immunosuppressive therapy; 5. previous neurological or mental disorders or preoperative neurological examination with positive signs; 6. Education level below primary school level (6 years); 7. can not complete the test or incomplete data; 8. Cardiac and cerebrovascular accidents occurred during perioperative period.

Design outcomes

Primary

Measure	Time frame
insulin;c-peptide;cognitive function;blood glucose;	—

Secondary

Measure	Time frame
Body Mass Index;Cardiopulmonary bypass time;	—

Countries

China

Contacts

Public ContactYin Hesong

Chengdu Second People's Hospital

hesongyin@126.com+86 182 8081 5743

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026