Negative emotions in the early postoperative period after thoracoscopy
Conditions
Interventions
Opioid-free anesthesia group:Anesthesia induces a loading dose of dexmedetomidine 0.5 µg/kg (within 10 minutes), followed by midazolam 0.05 mg/kg, esketamine 0.3~0.5 mg/kg, propofol 1~2 mg/kg, and cis
Opioid anesthesia group:Anesthesia induced midazolam 0.05 mg/kg, sufentanil 0.3~0.5 µg/kg, propofol 1~2 mg/kg and cisatracurium 0.2 mg/kg were induced. Propofol 4~6 mg/(kg · h), sevoflurane (1~2%), re
Sponsors
Affiliated Hospital of Chengdu University
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: (1) Preoperative imaging confirmed pulmonary nodules, and it is planned to perform video-assisted thoracoscopic surgery with general anesthesia by bronchial intubation, including: pulmonary wedge resection, segmental resection, partial pneumonectomy and lobectomy; (2). Age 18-80 years old; ASA I~III; Body Mass Index (BMI) is 18.5 ~ 30kg/m^2; (3) Patients and their families agree to participate in this study and sign the informed consent form; (4) Be able to understand the use and content of research-related scales.
Exclusion criteria
Exclusion criteria: (1) Patients with severe cardiovascular and cerebrovascular diseases or hepatic and renal insufficiency; (2) Patients who used immunosuppressants during perioperative period; (3) People who are addicted to or dependent on opioids or hypnotics; (4) Patients with preoperative behavioral disorder or mental illness who have used psychotropic drugs; (5) History of chronic pain; (6) Those who have contraindications to the use of narcotic drugs, dexmedetomidine, estaketamine and non-steroidal anti-inflammatory drugs in this experiment.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Hospital Anxiety and Depression Scale score;Brain-derived neurotrophic factor;Interleukin-6;Interleukin-10; | — |
Secondary
| Measure | Time frame |
|---|---|
| Blood pressure;Heart rate;Pain scores;Generalized anxiety disorder scale score; | — |
Countries
China
Contacts
Public ContactJing Deng
Affiliated Hospital of Chengdu University
Outcome results
None listed