Perioperative cognitive dysfunction and other postoperative anesthesia related complications
Conditions
Interventions
Remifentanil Group:The use of remifentanil during the process of anesthesia
Conventional Opioid Group:The use of sufentanil during the process of anesthesia
Remifentanil combined with thoracic paravertebral nerve block group.:The application of remifentanil combined with thoracic paravertebral nerve block during the process of anesthesia.
The application of conventional opioids combined with thoracic paravertebral nerve block.:The application of conventional opioids combined with thoracic paravertebral nerve block during the process of
Sponsors
The Affiliated Hospital of Qingdao University
Eligibility
Sex/Gender
All
Age
65 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Age>=65 years old; 2. Gender is not limited; 3. Elective surgery (such as general surgery, thoracic surgery, orthopedic spine surgery, urological surgery, gynecological surgery) is planned; 4. ASA Class I-III; 5. Voluntarily sign the informed consent form.
Exclusion criteria
Exclusion criteria: 1. Patients with severe impairment of consciousness or psychiatric diseases (schizophrenia, mania, bipolar abnormalities, mental confusion, etc.) and cognitive dysfunction before surgery; 2. Severe cardiovascular and cerebrovascular events (acute heart failure, severe angina pectoris, or unstable angina or myocardial infarction, severe arrhythmia, pulmonary embolism, pulmonary edema, non-fatal stroke) within 3 months; 3. Local anesthesia surgery; 4. Patients who have undergone day surgery or are admitted and discharged within 48 hours.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Cognitive function test;Montreal Cognitive Assessment (MoCA); | — |
Secondary
| Measure | Time frame |
|---|---|
| Postoperative awakening time;The time of postoperative tracheal tube removal.;Pain score ;Blood routine test;Inflammatory factors;Immune factors; | — |
Countries
China
Contacts
Public ContactPeng Wang
The Affiliated Hospital of Qingdao University
Outcome results
None listed