Addiction to drugs
Conditions
Interventions
Control group:Propofol + normal saline
Fentanyl group:Propofol and fentanyl
Nalbuphine group:Propofol + nalbuphine
Sponsors
Suzhou Xiangcheng People's Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. Age 18 to 75 years old; 2. Body mass index (BMI) 18.5 to 30 kg/m^2; 3. ASA classification I to III; 4. Mallampati classification I to III; 5. Patients undergoing painless gastroscopy and colonoscopy procedures; 6. Patients who can understand the entire clinical research process and sign an informed consent form.
Exclusion criteria
Exclusion criteria: 1. Patients with severe heart, lung, and brain diseases; 2. Patients with severe obstructive sleep apnea syndrome; 3. Patients with severe esophageal or gastrointestinal motility disorders; 4. Patients who have been taking opioids or sedatives for a long time and show a clear dependence on sedation or analgesia; 5. Patients who are allergic to propofol, fat emulsion, soy or egg products; 6. Pregnant women or women who are breastfeeding; 7. Patients with language communication disorders, who are unable to cooperate or have mental health disorders; 8. Patients with Mallampati classification IV, mouth opening <2.5cm; who are predicted to have or have had difficulty with the airway or have an abnormal history of surgical anesthesia recovery; 9. Long-term alcoholics.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Center for the Study of Addictions-Morphine-Amphetamine subscale (MBG); | — |
Secondary
| Measure | Time frame |
|---|---|
| Center for Addiction Research Scale (ARCI) total score;Center for Addiction Research Scale - pentobarbital, chlorpromazine, Alcohol subscale (PCAG) score;Center for Addiction Research Scale (LSD) score;Pittsburgh Sleep Quality Index (PSQI);Dreams: No dreams, good dreams (pleasant, positive), nightmares (unpleasant, negative);Surgical Volume Index (SPI);Time to recovery;Time awake;Time of induction;Satisfaction: (VAS score 0-10, endoscopists);Center for the Study of Addictions-Morphine-Amphetamine subscale (MBG); | — |
Countries
China
Contacts
Public ContactLi Yan;Ma Chuntao
Suzhou Xiangcheng People's Hospital
Outcome results
None listed