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Efficacy and safety of four-factor prothrombin complex concentrate in patients with massive bleeding: a retrospective cohort study

Efficacy and safety of prothrombin complex concentrate for patients with massive bleeding: a retrospective cohort study

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR2500096573
Enrollment
Unknown
Registered
2025-01-26
Start date
2023-05-08
Completion date
Unknown
Last updated
2025-02-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Massive Blood Loss

Interventions

Control group:None
Prothrombin complex concentrate group:None

Sponsors

Peking Union Medical College Hospital
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 100 Years

Inclusion criteria

Inclusion criteria: 1. Age: 18-100 years old; 2. Massive bleeding (blood loss of 2000ml or more, or transfusion of 10 units or more of red blood cells).

Exclusion criteria

Exclusion criteria: 1. Patients with missing information; 2. Non-hospitalized patients.

Design outcomes

Primary

MeasureTime frame
Post-treatment red blood cell transfusion;—

Secondary

MeasureTime frame
Thromboembolic events ;Acute kidney injury;Duration of mechanical ventilation.;Duration of intensive care unit.;Duration of hospital stay.;—

Countries

China

Contacts

Public ContactLulu Ma

Peking Union Medical College Hospital

malulu@pumch.cn+86 138 1104 9619

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026