Ischemic Stroke
Conditions
Interventions
the high-frequency treatment group:High-frequency rTMS (5 Hz)
the low-frequency treatment group:Low-frequency rTMS (1 Hz)
normal control group:none
Sponsors
Beijing Hospital
Eligibility
Sex/Gender
All
Age
40 Years to 80 Years
Inclusion criteria
Inclusion criteria: (1) Healthy Control Group Inclusion Criteria: Aged 40-80 years No history of central nervous system diseases, and no evident intracranial lesions on brain MRI Right-handed according to the Edinburgh Handedness Inventory (2) Patient Group Inclusion Criteria: Aged 40-80 years First-time stroke, with normal limb function and ability to perform daily activities prior to the stroke Stroke onset within 2 weeks to 1 year Radiological diagnosis of ischemic stroke, with the responsible blood vessels being the left internal carotid artery system, right internal carotid artery system, or the vertebrobasilar artery system (single vascular system). The cause is atherosclerotic large artery disease. For patients with lesions in the vertebrobasilar system, the lesion only affects the corticospinal tract or motor neuron nuclei of the limbs, and does not involve the cerebellum or cranial nerves. Conscious and stable vital signs Unilateral hemiplegia Right-handed according to the Edinburgh Handedness Inventory
Exclusion criteria
Exclusion criteria: (1) Healthy Control Group Exclusion Criteria: Good cognitive function, able to cooperate with examinations and treatments, with no hearing, vision, sensory, intellectual, mental disorders, aphasia, or hemispatial neglect Bone, joint, and muscle diseases affecting upper limb function Other severe neurological disorders and chronic systemic diseases, such as malignancies, severe heart, lung, liver, or kidney damage Participation in other clinical studies Contraindications for functional near-infrared spectroscopy (fNIRS) examination (2) Patient Group Exclusion Criteria: Contraindications for functional near-infrared spectroscopy (fNIRS) examination Pregnancy, epilepsy, or contraindications for rTMS treatment (such as alcohol or drug addiction) Good cognitive function, able to cooperate with examinations and treatments, with no hearing, vision, sensory, intellectual, mental disorders, aphasia, or hemispatial neglect Bone, joint, and muscle diseases affecting upper limb function Other severe neurological disorders and chronic systemic diseases, such as malignancies, severe heart, lung, liver, or kidney damage Participation in other clinical studies
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| FMA-UL; | — |
Secondary
| Measure | Time frame |
|---|---|
| Simple Reaction Time, Choice Reaction Time;STEF Simple Upper Extremity Function Assessment, DASH Score, Barthel Index, Hand Function Grading for Hemiplegia; | — |
Countries
China
Contacts
Public ContactNa Ye
Beijing Hospital
Outcome results
None listed