Lack of concentration, excessive guilt or low self-worth, feeling hopeless about the future, thoughts of death or suicide, sleep disturbances, changes in appetite or weight, feeling extremely tired or lacking energy.
Conditions
Interventions
Sponsors
Eligibility
Inclusion criteria
Inclusion criteria: 1.Queue 1: (1) Outpatient patients at our hospital, aged 10-19 years old, who meet the diagnostic criteria for adolescent depression in DSM-5; (2) HAMD-17>7 points, CGI-S >= 3 points, Young Mania Rating Scale, YMRS>= 6, Right handed; (3) Sign informed consent form; 2.Queue 2: (1) High school students and young people seeking help from the psychological hotline in this city; (2) Age: 10-19 years old. (3) Sign the informed consent form.
Exclusion criteria
Exclusion criteria: a. History of loss of consciousness due to organic brain disease or head trauma; b. Any significant or unstable cardiovascular, respiratory, neurological (including epilepsy or significant cerebrovascular disease, head injury), renal, hepatic, endocrine or immunological or organic disease causing anxiety, History of depression or current infection, trauma, etc.; c. Arbitrary contraindication to MRI, or structural abnormalities of the brain found on magnetic resonance examination; d. Have hearing problems (inability to hear or understand the examiner's speech under normal conversation); e. Psychoactive substance abuse and dependence History; f. Long-term use of anticholinergic drugs. g. Those who have serious suicidal ideation and behavior; h. Antidepressant or ECT therapy or rTMS therapy within six months.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Based on scale evaluation;Accuracy;Sensitivity;Specificity; | — |
Secondary
| Measure | Time frame |
|---|---|
| Based on speech intonation;Positive predicative value;Negative predictive value; | — |
Countries
China
Contacts
Huzhou Third Municipal Hospital