Moderate-severe head injury
Conditions
Interventions
Experimental group:A 25% human blood albumin transfusion is given in addition to conventional hyperosmolar therapy to maintain albumin levels above 35 g/dL
Control group:Follow a protocol for dehydration and intracranial pressure reduction based on hypertonic drugs such as mannitol
Sponsors
Changxing County Hospital of Traditional Chinese Medicine
Eligibility
Sex/Gender
All
Age
18 Years to 74 Years
Inclusion criteria
Inclusion criteria: 1. Age>=18 years; 2. The patient has a craniocerebral injury, and there is a basis for imaging to support the diagnosis; 3. GCS score of 12 and below; 4. Not participating in other clinical intervention trials; 5. The patient or his/her legal representative has informed consent and voluntarily participates in the study.
Exclusion criteria
Exclusion criteria: 1. Previous liver diseases such as liver cirrhosis; 2. Death within 48 hours of admission to the ICU; 3. Concomitant severe mental illness; 4. Pregnancy; Age>=75 years; Cardiac insufficiency, cardiac function grade III-IV; 5. For some reasons, the patient refuses to undergo relevant examinations or is unable to obtain relevant complete information; 6. Those who need to discontinue the study due to force majeure factors such as change in condition, death or transfer to hospital.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 28-day death rate; | — |
Secondary
| Measure | Time frame |
|---|---|
| Length of ICU stay;Duration of mechanical ventilation;Hospitalization costs;Acute Physiology and Chronic Health Evaluation II;Glasgow Coma Scale, GCS; | — |
Countries
China
Contacts
Public ContactZhang Yougui
Changxing County Hospital of Traditional Chinese Medicine
Outcome results
None listed