HIV/HBV co-infection
Conditions
Interventions
ART combined with interferon group:None
Sponsors
Guangzhou Eighth Peoples Hospital Guangzhou Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1.Age 18-65 years old, gender unrestricted. 2.Meeting the People's Republic of China Health Industry Standard (WS293-2008) - "AIDS and HIV Infection Diagnostic Criteria", confirmed as HIV-1 infected. 3.HBsAg positive for more than 6 months. 4.At least 1 year of ART treatment prior to screening, and currently undergoing ART treatment with HBsAg 200 cells/µL and HIV RNA<20 copies/ml.
Exclusion criteria
Exclusion criteria: 1.Pregnant, nursing, planning pregnancy, or with severe mental disorders or uncontrolled epilepsy. 2.Co-infected with Hepatitis A, C, D, or E viruses. 3.With other chronic liver diseases like autoimmune hepatitis, drug induced hepatitis, alcoholic hepatitis, genetic metabolic liver diseases, or moderate to severe fatty liver. 4.With autoimmune diseases like rheumatoid arthritis, psoriasis, or lupus. 5.Post organ transplant, planning organ transplant, diagnosed or suspected of liver cancer or other malignant tumors, or undergoing immunosuppressive treatment. 6.With severe diseases of heart, lungs, kidneys, brain, retinal disorders, or uncontrolled hypertension or diabetes. 7.Excessive alcohol (average daily alcohol intake >40g for men, >20g for women) or drug users. 8.Participated in other interventional trials within the last three months, or other situations deemed inappropriate for inclusion by researchers. 9.ALT less than 10 times the upper limit of normal, total bilirubin less than 2 times the upper limit of normal; neutrophil count > 1.5 × 10^9/L, platelet count > 80 × 10^9/L (for the ART combined with interferon group only). 10.Non-invasive liver fibrosis markers, such as APRI 60 mL/min/1.73 m². (for the ART combined with interferon group only).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Hepatitis B surface antigen seroclearance; | — |
Countries
China
Contacts
Public ContactLi Linghua
Guangzhou Eighth Peoples Hospital Guangzhou Medical University
Outcome results
None listed