Post-transplant diabetes
Conditions
Interventions
Application of Proline Henggliflozin Tablets:NA
Sponsors
The Eighth Medical Center of PLA General Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. Meet the diagnostic criteria for PTDM or type 2 diabetes. 2. Age 18-75 years old. 3. Time after kidney transplantation >= 1 year and = 45 ml/min calculated according to the CKD-EPI formula.
Exclusion criteria
Exclusion criteria: 1. Repeated transplantation within 1 year after transplantation. 2. Concurrent infection, history of recurrent urinary tract infection. 3. Uncorrected acute complications of diabetes. 4. Concurrent rejection of renal transplantation. 5. Infectious diseases or other diseases that persistently affect renal function. 6. Malnutrition. 7. Participants with known allergies to SGLT2 inhibitors or any excipients of the product. 8. Pregnant or lactating women. 9. Patients with moderate and severe hepatic impairment (Child-Pugh B and C).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| time in range on CGM;fasting blood glucose;postloading blood glucose;HbA1c; | — |
Secondary
| Measure | Time frame |
|---|---|
| UACR;serum UA;blood pressure;Heart rate;weight;BMI;total insulin dose ;Cardiovascular disease incidence;Graft survival rate;all-cause mortality; | — |
Countries
China
Contacts
Public ContactJing Shen
The Eighth Medical Center of PLA General Hospital
Outcome results
None listed