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The Relationship Between Glutaredoxin-1 and Early Deterioration in Acute Ischemic Stroke Patients and the Risk of Stroke Recurrence Within One Year: A Multicenter Study

Glutaredoxin-1 and Its Association with Early Neurological Deterioration and One-Year Stroke Recurrence Risk in Acute Ischemic Stroke Patients: A Multicenter Prospective Cohort Study

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR2500096526
Enrollment
Unknown
Registered
2025-01-24
Start date
2025-01-24
Completion date
Unknown
Last updated
2025-01-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Ischemic stroke

Interventions

Non-Early Neurological Deterioration group, Non-END group:None
Recurrent Stroke Group:None
Early Neurological Deterioration group, END group:None
Non-Recurrent Stroke Group:None

Sponsors

The First Affiliated Hospital of Chongqing Medical University
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to No maximum

Inclusion criteria

Inclusion criteria: 1.The patients were admitted within 72 hours after the onset of symptoms, and blood samples were obtained within 72 hours of symptom onset; 2.All patients met the diagnostic criteria for acute ischemic stroke and had corresponding cranial MRI or cranial CT evidence consistent with their symptoms; 3.Age>=18 years; 4.The patient or their family provided written consent to participate in the study.

Exclusion criteria

Exclusion criteria: 1.Patients with concomitant severe inflammatory or infectious disease; 2.Patients with concomitant severe cardiac, liver, or renal dysfunction; 3.A history of prior stroke or a pre-onset mRS score exceeding 1; 4.The time from symptom onset to discharge was less than 7 days; 5.Patients lost to follow-up.

Design outcomes

Primary

MeasureTime frame
Early neurological deterioration;Recurrent ischemic stroke within one year.;

Secondary

MeasureTime frame
Poor neurological outcome;Symptomatic hemorrhagic transformation;Post-stroke cognitive impairment;Post-stroke depression;

Countries

China

Contacts

Public ContactQin Yang

The First Affiliated Hospital of Chongqing Medical University

xyqh200@126.com+86 23 89011911

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026