preterm birth
Conditions
Interventions
Comparison group 2:Low-dose dexamethasone use
control group:Conventional high-dose dexamethasone use
Comparison group 1:Low-dose betamethasone sodium phosphate use
Sponsors
Chongqing Health Center for Women and Children
Eligibility
Sex/Gender
Female
Inclusion criteria
Inclusion criteria: 1 Pregnant women being able to sign informed consent; 2 single, twin or multiple pregnancies; 3 28+0-34+6 gestational weeks; 4 Pregnant women clinically assessed to be at high risk of imminent delivery (i.e., within 1 to 14 days after the start of treatment). High risk of delivery is defined as: 1 The. length of the cervix is at least 3cm, with contraction and unbroken amniotic membrane; 2. premature rupture of membranes; 3. Preterm birth is expected within 1 to 14 days of planned randomization due to any other indication (mode of delivery is determined by the obstetrician).
Exclusion criteria
Exclusion criteria: 1? The pregnant women will be excluded, if delivery is expected to be less than 24 hours or more than 14 days later; 2? Intrauterine death; 3?The presence of fetal distress requiring immediate termination of pregnancy; 4? Major fetal structural or genetic abnormalities; 5? Corticosteriods contraindications; 6? Prenatal corticosteriods was used during this pregnancy; 7? The amniotic membrane is broken with regular contractions (at least once every 5 minutes) and the uterine opening larger than 3 cm; 8? Uterine opening 8cm or more; 9? No accurate due date.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The number of stillbirths/newborns who were treated with surfactants at any time within 72 hours of birth and/or perinatal deaths (prenatal stillbirths or deaths within 7 days of birth);The number of newborns who completed the entire treatment and delivered within 1 to 14 days after the start of treatment; | — |
Secondary
| Measure | Time frame |
|---|---|
| Physical and Biochemical index; | — |
Countries
China
Contacts
Public ContactHongbo Qi
Chongqing Health Center for Women and Children
Outcome results
None listed