major depressive disorder
Conditions
Interventions
HBOT + Medication group:HBOT + medication therapy
Medication group:Medication therapy
Sponsors
Chaohu Hospital of Anhui Medical University
Eligibility
Sex/Gender
All
Age
13 Years to 18 Years
Inclusion criteria
Inclusion criteria: (1) diagnosed as major depressive disorder that meets the diagnostic criteria in the Diagnostic and Statistical Manual of Mental Disorders, 5th edition (DSM-5), as determined by a structured clinical interview with two psychiatrists of attending grade and above; (2) 17-item Hamilton Depression Scale (HAMD) score >= 18 at enrolment; (3) aged between 13 and 18 years old, right-handed, with some reading ability; (4) subjects or their guardians sign an informed consent form; (5) No antidepressant drugs prior to enrolment or off antidepressant drugs for >= 2 weeks (fluoxetine for >= 5 weeks).
Exclusion criteria
Exclusion criteria: (1) combined with other mental disorders; (2) combined with serious somatic diseases, nervous system diseases, and mental retardation; (3) unable to cooperate or uncooperative with the assessment; (4) presence of relative and absolute contraindications to hyperbaric exposure, e.g. claustrophobia, untreated pneumothorax with glaucoma, concomitant administration of disulfiram or antineoplastic drugs; (5) physical therapy such as hyperbaric oxygen therapy (HBOT), MECT, transcranial magnetic stimulation therapy, transcranial direct current therapy, and systemic psychotherapy in the previous 6 months.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Clinical symptoms;Multimodal MRI;Hematological index;Cognitive function; | — |
Countries
China
Contacts
Public ContactLei Xia
Chaohu Hospital of Anhui Medical University
Outcome results
None listed