Depressive disorder
Conditions
Interventions
Experimental group:Non-convulsive electroconvulsive therapy (MECT)
Control group:Conventional antidepressant medication
Sponsors
Quzhou Third Hospital
Eligibility
Sex/Gender
All
Age
12 Years to 60 Years
Inclusion criteria
Inclusion criteria: 1.Age 12~ 60 years old; 2.Patients with normal cognitive function assessment (score >= 90 on the Wechsler Intelligence Test); 3.Enrollment was based on patients who met the diagnostic criteria for major depressive disorder in the Diagnostic and Statistical Manual of Mental Disorders-IV (DSM-IV) and were diagnosed with depressive disorder; 4.Baseline status at enrollment HAMD-24 score >= 35; 5.Understand the research content and sign the informed consent form;
Exclusion criteria
Exclusion criteria: 1.With major physical diseases, such as cardiovascular and cerebrovascular diseases, intracranial space-occupying diseases, intracranial hypertension, severe respiratory diseases and serious trauma, fractures, infectious diseases, etc; 2.Metallic foreign bodies or special implants in the body, such as pacemakers or intracranial electrodes; 3.History of convulsions; 4.History of psychoactive substance abuse or dependence; 5.At the same time, combined diagnosis of other psychiatric diseases, such as organic mental disorders, schizophrenia, loneliness spectrum disorder, etc; 6.The family member does not agree to MECT treatment or the doctor in charge does not consider it suitable for MECT treatment from a therapeutic perspective; 7.Patients treated with repetitive transcranial magnetism;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Formaldehyde concentration;Formaltase-urine-sensitive methyloxidase (SSAO);Sarcosine dehydrogenase (SARDH);Formaldehyde Dehydrogenase (FDH);Alaldehyde dehydrogenase 2 (ALDH2);Coenzyme Q10;Hydrogen peroxide, H2O2;24-Item Hamilton Depression Rating Scale Score; | — |
Countries
China
Contacts
Public ContactJuntao Zhu
Quzhou Third Hospital
Outcome results
None listed