Migraine
Conditions
Interventions
without aura migraine group:None
Healthy control group:None
Sponsors
The First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Chinese Medicine)
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1.Meet the diagnostic criteria for migraine without aura selected and formulated in this clinical study; 2.The enrolled patients are between 18 and 65 years old, the first onset of migraine is <=50 years old, and have not yet received treatment or their condition has not improved significantly after treatment; 3.migraine attacks in the past 12 weeks; 4.At least one migraine attack per month on average; 5.without serious dysfunction of heart, brain, liver and kidney function; 6.No metal in the body, meets the requirements of cranial MRI examination, and no claustrophobia;
Exclusion criteria
Exclusion criteria: 1.Non-primary headache, which is one of the symptoms of other diseases or headache secondary to other diseases, such as post-traumatic headache, cerebral infarction, hypertensive headache and other brain trauma and intracranial organic lesions; 2.Have taken oral or topical migraine-related medications within 1 week, or have a history of drug abuse; 3.With severe cardiopulmonary insufficiency, serious primary diseases such as liver, kidney, digestive and hematopoietic systems, and tumors, somatization disorders, or mental disorders; 4.Pregnant, lactating women and women preparing for pregnancy.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Number of migraine attacks;Migraine severity;Migraine duration;Migraine associated symptoms;Headache Impact Test-6 (HIT-6) score;The Migraine Disability Assessment questionnaire (MIDAS) score;Migraine-Specific Quality of Life instrument (MsQOL) score;Patient Health Questionnaire-9 (PHQ-9) score;Generalized Anxiety Disorder-7 (GAD-7) score;MRI sequences for migraine (sagittal T1, axial T2, SWAN, ASL, thalamus spectrum, DTI, BOLD).; | — |
Countries
China
Contacts
Public Contactzhengxiang zhang
The First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Chinese Medicine)
Outcome results
None listed