Postoperative acute pain
Conditions
Interventions
C group:Conventional General Anesthesia
D group:tDCS stimulation
K group:adjunctive intravenous use of esketamine
DK group:adjunctive intravenous use of esketamine+tDCS stimulation
Sponsors
Xuzhou Central Hospital
Eligibility
Sex/Gender
All
Age
60 Years to No maximum
Inclusion criteria
Inclusion criteria: 1.> = age 60 years; 2. Elective orthopedic surgery under general anesthesia, 1 = operation time =4h; 3. ASA grade II-III; 4. No communication barriers, clear consciousness; 5. BMI of 18.5-28 kg/m2; 6. Voluntary use of postoperative intravenous analgesic devices; 7. In line with ethics, the patient voluntarily underwent the test and signed the informed consent form.
Exclusion criteria
Exclusion criteria: 1. Those who have contraindications or allergies to esketamine and other anesthetic drugs; 2. Identify/suspect those who have abused or used narcotic sedative analgesics for a long time; 3. Patients with severe hypertension and severe cardiovascular disease; 4. Any cerebrovascular accident within 3 months; 5. Patients with pulmonary hypertension, intracranial pressure or intraocular hypertension; 6. Those with a history of severe mental illness, central nervous system injury or cognitive dysfunction; 7. Patients with severe liver and kidney insufficiency; 8. History of use of antidepressant and other psychotropic drugs; 9. Pregnant; 10. Implantation of pacemakers or other metals in the body; 11. Refusal to sign informed consent.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Postoperative 24-hour pain score; | — |
Secondary
| Measure | Time frame |
|---|---|
| Postoperative 48-hour pain score;Postoperative 72-hour pain score;Post-extubation pain score;Post-anesthesia recovery room awakening quality evaluation; Postoperative adverse reactions; | — |
Countries
China
Contacts
Public ContactLiwei Wang
Xuzhou Central Hospital
Outcome results
None listed