Infection related to sexual fractures
Conditions
Interventions
Gold Standard:The gold standard is the pathological examination of surgical tissue specimens: intraoperative materials are taken for pathological examination, conventional HE staining light microscopi
Index test:The enrolled patients with suspected infection associated with long bone fracture (FRI) of the limbs underwent 99mTc-FAPI SPECT/CT and 18F-FDG-PET/CT within 1 week before surgery, respectiv
Sponsors
The First Affiliated Hospital of Army Medical University
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Age>=18 years. 2. History of open fracture or open/closed fracture internal fixation surgery on the long bones of the limbs. 3. Clinically suspected chronic fracture-related infection and undergoing surgery in our hospital. According to the expert consensus published at home and abroad, the criteria for suspicion of fracture-related infection include: Meet at least one clinical manifestation criterion: progressive pain, wound hematoma, exudation, etc. in a localized new-onset non-weight-bearing state, or local sinus tracts, pus, poor wound healing, etc. Meets at least one imaging criterion (CT or MRI): osteolysis, loosening of internal fixation, dead bone formation, nonunion, non-fracture site, or healed fracture site at the fracture end or around the implant Periosteal reaction. With or without laboratory abnormalities: serum inflammatory markers such as erythrocyte sedimentation rate, white blood cell count, and C-reactive protein are twice elevated or persistently elevated 4. Each patient has at least one infectious lesion that meets the above criteria (this study is based on lesions Subjects, i.e., the sample size is the number of lesions), if a patient has more than one lesion, each lesion is performed Imaging and pathological tests 5. Masquelet reconstruction treatment is proposed 6. Agree to perform 99mTc-FAPI SPECT/CT imaging and 18F-FDG PET/CT imaging. 7. Able to cooperate with the completion of examinations and follow-ups.
Exclusion criteria
Exclusion criteria: 1.Clinically diagnosed as acute fracture related infection. 2.Tumor patients. 3.FAP may be highly expressed in diseases such as IgG4 related diseases, rheumatoid arthritis, osteoarthritis, myocardial infarction, cirrhosis, and pulmonary fibrosis. 4.Patients with severe heart, lung, liver, and kidney dysfunction. 5.Pregnant or lactating women. 6.Patients who are unable to cooperate in completing the examination and follow-up.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Diagnostic sensitivity;Specificity;Positive predictive value;Negative predictive value;Accuracy; | — |
Countries
China
Contacts
Public ContactHuang Dingde
The First Affiliated Hospital of Army Medical University
Outcome results
None listed