Anxiety symptoms
Conditions
Interventions
a-cTBS real stimulation group:The figure-eight stimulation coil is localized to the right dorsolateral prefrontal cortex (DLPFC), which was determined by using MNI coordinates (x,y,z =-44,40,29) in th
a-cTBS sham stimulation group:In the a-cTBS pseudo-stimulation group, the subject's operating flow is consistent with that of the true stimulation group, where the subject's head is first fixed in a s
Sponsors
Affiliated Kangning Hospital of Ningbo University
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Age 18~65 years old; 2. Meet the diagnostic criteria for anxiety disorders in the Diagnostic and Statistical Manual of Mental Disorders (DSM-5). 3. HAMA total score >=14 points; 4. Right hand; 5. The patient's physical examination, medical history, vital signs, hematuria and stool routine, liver and kidney function, electrolytes, electrocardiogram, electroencephalogram and other indicators were normal; 6. After fully understanding the safety of transcranial magnetic stimulation (TMS), willing to actively cooperate with the treatment, and signed informed consent by the person and his family.
Exclusion criteria
Exclusion criteria: 1. Age 65 years old; 2. Have a history of severe physical illness and anxiety caused by other psychoactive substances and non-dependent substances; 3. Patients with metal or electronic devices built into their bodies, such as intracranial metal foreign bodies, cochlear implants, pacemakers, stents and other metal foreign bodies; 4. Have a risk of seizures, have previous craniocerebral diseases, head trauma, alcoholism, electroencephalogram abnormalities, MRI evidence of brain structural abnormalities, or have a family history of epilepsy; 5. Those who have psychotic symptoms and need to be combined with antipsychotic drugs; 6. Received ECT or other physical therapy within 2 months before enrollment.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Hamilton Anxiety Scale score; | — |
Secondary
| Measure | Time frame |
|---|---|
| Near Infrared Imaging (fNIRS);Resting state/task state EEG;Other scales, etc. (anxiety, suicide, cognition, etc.);Transcranial magnetoencephalography (TMS-EEG);Transcranial magneto-myography (TMS-MEP);Paired pulse stimulation;3.0T magnetic resonance imaging (MRI); | — |
Countries
China
Contacts
Public ContactYu Chang
Affiliated Kangning Hospital of Ningbo University
Outcome results
None listed