Major depressive disorder
Conditions
Interventions
Major depressive disorder(episode):None
Major depressive disorder(remission/partial remission):None
Healthy control:None
Sponsors
The Second Xiangya Hospital of Central South University
Eligibility
Sex/Gender
All
Age
18 Years to 45 Years
Inclusion criteria
Inclusion criteria: Major Depressive Disorder(MDD) Group: 1.Age range from 18 to 15 years old, gender not limited; 2.Right handed; 3.If the patient meets the diagnostic criteria for depression in the Diagnostic and Statistical Manual of Mental Disorders,Fifth Edition (DSM-5); Currently in a state of depressive episode and with a Hamilton Depression Rating Scale (HAMD-17) score of >= 17 points, included in the MDDe group; If the patient has previously met the diagnostic criteria for depression in the 5th edition of the Diagnostic and Statistical Manual of Mental Disorders (DSM-5) but is currently in partial remission (with symptoms of a previous major depressive episode that do not currently meet all diagnostic criteria, or without any significant symptoms of depression for less than 2 months after the end of an episode) or complete remission (without any obvious signs or symptoms of depression in the past 2 months), and currently has a Hamilton Depression Rating Scale (HAMD-17) score<17 points, they are included in the remission/partial remission group (MDDpr/r); 4.Refractive error <=± 6 diopters (D) spherical and ± 2D cylindrical lenses; 5.Abstain from psychotropic, vascular, or ophthalmic drugs for at least four months; 6.No alcohol consumption or use of psychotropic drugs within 24 hours prior to OCTA testing; 7.Subject informed consent, voluntary participation, and voluntary signing of informed consent forms, voluntary participation, voluntary signing of informed consent form. Healthy controls(HC): (1) Be between the ages of 18 and 45, regardless of gender; (2) Right-handed; (3) No history of psychiatric illness, neurological disease, or use of psychotropic drugs; (4) Refractive error =±6 diopter (D) spherical and ±2D cylindrical mirrors; (4) Abstinence from psychotropic drugs, vascular drugs or ophthalmic drugs for at least four months; (5) Refrain from drinking alcohol or taking psychotropic drugs within 24 hours prior to the OCTA test; (6) Subjects gave informed consent, voluntarily participated, and voluntarily signed the informed consent form.
Exclusion criteria
Exclusion criteria: Major Depressive Disorder(MDD) Group: 1.The subject meets the diagnostic criteria for other psychiatric disorders in ICD-10, including schizophrenia spectrum and other psychiatric disorders, bipolar and related disorders, anxiety disorders, obsessive-compulsive and related disorders, somatic symptoms and related disorders, or has a history of such diseases; 2.Organic mental disorders, such as depression caused by hypothyroidism; Depression caused by psychoactive substances or non addictive substances; 3.Suffering from any ophthalmic disease, including epiretinal membrane, age-related macular degeneration, glaucoma, macular hole, refractive errors exceeding ± 6 diopters (D) spherical and ± 2D cylindrical lenses, macular vitreous warts, and pathological myopia; 4.Patients with diabetes associated by nervous system diseases, uncontrolled hypertension, lung disease, severe heart disease, kidney disease, liver disease or any type of tumor; Patients with diabetes accompanied by nervous system diseases, uncontrolled hypertension, lung disease, severe heart disease, kidney disease, liver disease or any type of tumor; 5.Female participants who are currently breastfeeding or have tested positive for pregnancy during the screening period or trial process; 6.Smoking. Healthy controls(HC): (1) Have any ophthalmic disease, including epiretinal membrane, age-related macular degeneration, glaucoma, macular hole, refractive error over ±6 diopter (D) spherical and ±2D cylindrical, macular drusenos, and pathological myopia. (2) Patients with diabetes mellitus with neurological disease, uncontrolled hypertension, lung disease, severe heart disease, kidney disease, liver disease, or any type of tumor; (3) Female subjects who are lactating during the screening period or during the test or have a positive pregnancy test; (4) Smoking.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Binocular axial parameters;Visual sensory function;Visual cognitive function;Resilience;Neurovascular parameters of binocular retinal structure;Vision; | — |
Secondary
| Measure | Time frame |
|---|---|
| Anxiety;Depression;Sleep quality;Psychotic symptom;Anhedonia;Suicide risk;Childhood trauma;Personality;Perceived social support;Morning and night rhythms;Self-esteem;Self-disgust;Mania;Head imaging parameters; | — |
Countries
China
Contacts
Public ContactTao Haojuan
The Second Xiangya Hospital of Central South University
Outcome results
None listed