Thoracolumbar Fractures
Conditions
Interventions
Cyclopropylphenol Group:After the start of induction, the study drug cyclopofol 0.4mg.kg-1 was injected intravenously for a bolus time of 30s. When the patient loses consciousness (LoC), that is, the
Propofol Group:After the start of induction, the study drug propofol 2.0 mg.kg-1 was injected intravenously for a bolus time of 30s. When the patient lost consciousness (LoC), that is, the eyelash ref
Sponsors
Mindong Hospital Affiliated to Fujian Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: (1) Patients with thoracic and lumbar vertebra fractures who need to undergo elective surgery for endotracheal intubation; (2) Age 18-65 years old; (3) American Anesthesiologist Classification (ASA) Class I-III; (4) Body mass index (BMI): 18.5-30kg/m^2; (5) Be able to understand the process and methods of this study, and voluntarily participate in this study.
Exclusion criteria
Exclusion criteria: (1) Subjects who explicitly refuse to participate in this study; (2) Those with contraindications to general anesthesia or a history of previous anesthesia accidents; (3) Those who are known or suspected to be allergic or have contraindications to the excipients of propofol injection, cyclopropylphenol injection, benzodiazepines, opioids, muscle relaxants, etc.; (4) Using beta-blockers, anxiolytics, antidepressants; (5) Those suspected of abusing narcotic analgesics or sedatives, as well as alcoholics; (6) Those with a history of severe heart, brain, lung, liver, kidney or metabolic diseases, neuromuscular system diseases (such as myasthenia gravis), or mental illnesses; (7) Uncontrolled diabetes, preoperative systolic blood pressure > 180 mmHg and/or diastolic blood pressure > 110 mmHg, preoperative systolic blood pressure 100 beats/min, or having severe arrhythmia; (9) Having a history of acute respiratory tract infection within 2 weeks and not being cured, having respiratory insufficiency, obstructive pulmonary diseases, having a difficult airway or being judged as having difficult endotracheal intubation (modified Mallampati score of grade III or IV); (10) Those who have participated in any drug clinical trials within 1 month before screening; (11) Pregnant and lactating women; Women or men with fertility who are unwilling to use contraception throughout the trial period; Subjects (including male subjects) who have pregnancy plans within 1 month after the trial; (12) Subjects who are considered by the researchers to have any other factors that are not suitable for participating in this trial.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of intraoperative hypotension; | — |
Secondary
| Measure | Time frame |
|---|---|
| Injection pain;Pulse oxygen saturation;Breathe;Heart rate;Time from induction of anesthesia to LoC;The time from the end of maintenance drug administration to eye - opening.;The time from the end of maintenance drug administration to extubation.;The time from the end of maintenance drug administration to leaving the operating room.;Total operation time ;The induction and maintenance doses of cyclopropylphenol/propofol during the operation;The total dose of remifentanil.;The dosage of vasoactive drugs.;The usage situation of rescue medications during the maintenance period.;Modified Observer's Assessment of Alertness/Sedation;Visual Analogue Scale; | — |
Countries
China
Contacts
Public ContactDigui Weng
Mindong Hospital Affiliated to Fujian Medical University
Outcome results
None listed