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The molecular mechanism of glutamine inhibiting Drp1/FUNDC1 activation and reversing inflammation-induced mitophagy in amniotic epithelial cells to prevent and treat premature rupture of membranes in pre-preterm rupture of fetal membranes

The molecular mechanism of glutamine inhibiting Drp1/FUNDC1 activation and reversing inflammation-induced mitophagy in amniotic epithelial cells to prevent and treat premature rupture of membranes in pre-preterm rupture of fetal membranes

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR2500096429
Enrollment
Unknown
Registered
2025-01-23
Start date
2025-01-23
Completion date
Unknown
Last updated
2025-01-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Premature rupture of membranes

Interventions

Case group:None
Control group:None

Sponsors

Shenzhen Longgang District Maternity &Child Healthcare Hospital
Lead Sponsor

Eligibility

Sex/Gender
Female

Inclusion criteria

Inclusion criteria: 1) When the gestational age is less than 37 weeks, the pregnant woman feels that there is a lot of fluid flowing out of the vagina; vaginal speculum examination shows the accumulation of amniotic fluid in the posterior vaginal fornix or the amniotic fluid flowing out of the cervix. 2) When a small amount of vaginal fluid, obstetric examination and speculum examination cannot clearly diagnose or exclude pPROM, the following auxiliary examinations are used as diagnostic criteria: vaginal fluid pH >= 6.5 after excluding blood and urine and/or posterior vaginal fornix The secretion test for insulin-like growth factor was positive.

Exclusion criteria

Exclusion criteria: Exclude high-risk factors that cause PROM other than vaginal inflammation or may interfere with the test results: pregnant women with vaginal bleeding, trauma, cervical insufficiency, multiple pregnancy, systemic infectious diseases, autoimmune diseases, and serious medical and surgical complications. Sexual intercourse, vaginal disinfection, vaginal medication, systemic or vaginal antibiotics within 48 hours.

Design outcomes

Primary

MeasureTime frame
Amino acid levels;

Countries

China

Contacts

Public ContactLou Liu

Shenzhen Longgang District Maternity &Child Healthcare Hospital

wxliulou@163.com+86 13912352290

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026