Femoral neck fracture, Osteonecrosis of the femoral head
Conditions
Interventions
Liposomal bupivacaine group:Liposomal bupivacaine combined with bupivacaine hydrochloride
Control group:Ropivacaine combined with dexamethasone
Sponsors
Dazhou Central Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Age range of 18-80 years old, gender not limited; 2. BMI 18.5~32.5 kg/m^2; 3. Elective unilateral total hip replacement surgery; 4. American Society of Anesthesiologists (ASA) grades I-III; 5. Understand and voluntarily participate in this study, and sign the informed consent form.
Exclusion criteria
Exclusion criteria: 1. Severe insufficiency of vital organs; 2. Contraindications to nerve blocks; 3. Communication gap; 4. Allergy to the study drug; 5. History of chronic opioid usage; 6. Those who have participated in clinical trials of other drugs within the past 3 months; 7. Other situations that the researcher deems inappropriate to participate in this experiment.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Static and dynamic pain numerical rating scale scores; | — |
Secondary
| Measure | Time frame |
|---|---|
| Cumulative consumption of opioids;Motor weakness in the operated limb;Sensory block duration;Postoperative adverse events such as nausea, vomiting, dizziness, and skin itching;Incidence of postoperative rescue analgesia;Incidence of postoperative rebound pain; | — |
Countries
China
Contacts
Public ContactWu Wenshuang
Dazhou Central Hospital
Outcome results
None listed