Mild cognitive impairment
Conditions
Interventions
Mild cognitive impairment combined with abnormal heart rate variability in dorsolateral prefrontal cortex true stimulation group:Receiving true stimulation of the dorsolateral prefrontal cortex
Mild cognitive impairment combined with abnormal heart rate variability in ventromedial frontal cortex true stimulation group:True stimulation of ventromedial frontal cortex
Mild cognitive impairment combined with abnormal heart rate variability pseudo-stimulation group:Pseudo-stimulation of dorsolateral prefrontal cortex and ventromedial frontal cortex
Mild cognitive impairment combined with normal heart rate variability in dorsolateral prefrontal cortex position true stimulation group:Receiving true stimulation of the dorsolateral prefrontal cortex
Mild cognitive impairment combined with normal heart rate variability in ventromedial frontal cortex position true stimulation group:True stimulation of ventromedial frontal cortex
Mild cognitive impairment combined with normal heart rate variability pseudo-stimulation group:Pseudo-stimulation of dorsolateral prefrontal cortex and ventromedial frontal cortex
Cognitively unimpaired control group:None
Sponsors
Shenzhen People's Hospital
Eligibility
Sex/Gender
All
Age
60 Years to 75 Years
Inclusion criteria
Inclusion criteria: (1) Inclusion criteria of cognitively normal group: age 60-75 years old, gender unlimited, 1) no chief complaint of cognitive decline; 2) Montreal Cognitive Assessment Scale >26 points; 3) Simple mental state test scale: illiterate >17 points, primary school >20 points, junior high school and above >24 points; 4) All cognitive domains are within the normal range or the score of only one cognitive domain decreases; 5) Daily living ability was not impaired, daily living ability scale <16 points. (2) Inclusion criteria for mild cognitive impairment: age 60-75 years old, gender unlimited, 1) meet the 2011 National Institute on Aging and Alzheimer's Association (NIA-AAA) diagnostic criteria for mild cognitive impairment; 2) The course of the disease is more than 3 months; Or 3) the education level is junior high school or above; 4) Clinical dementia rating Scale <15.5 points, Montreal Cognitive Assessment Scale 18-26 points; 5) Hachinski Ischemia Scale score <4; 6) Daily living ability scale <22 points.
Exclusion criteria
Exclusion criteria: 1) other neurological diseases that can lead to cognitive decline (such as Parkinson's disease, vascular dementia, etc.); 2) meet the psychiatric diagnosis of diseases such as major depression and other mental diseases; 3) History of alcohol and drug abuse; 4) Visual and auditory impairment; 5) Received cognitive training and repeated transcranial magnetic stimulation therapy in the past six months; 6) There are other conditions that can not cooperate with or repeat the contraindications of transcranial magnetic stimulation.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Montreal Cognitive Assessment Scale score;Functional connection of EEG;Blood Oxygen-level Dependent;Heart Rate Variability; | — |
Secondary
| Measure | Time frame |
|---|---|
| Blood pressure complexity;Brachial-ankle pulse wave conduction velocity;Flow Mediated Dilation;Mini-mental State Examination score;Hamilton Depression Scale score;Hamilton Anxiety Scale score;Hachinski Ischemic Scale score;Activity of Daily Living Scale score; | — |
Countries
China
Contacts
Public ContactXin Jiang
Shenzhen People's Hospital
Outcome results
None listed