Major depressive disorders and depressive episodes in bipolar disorder
Conditions
Sponsors
Chaohu Hospital of Anhui Medical University
Eligibility
Sex/Gender
All
Age
13 Years to 18 Years
Inclusion criteria
Inclusion criteria: (1) diagnosed as major depressive disorder or depressive episode of bipolar disorder that meets the diagnostic criteria in the Diagnostic and Statistical Manual of Mental Disorders, 5th edition (DSM-5), as determined by a structured clinical interview with two psychiatrists of attending grade and above; (2) 17-item Hamilton Depression Scale (HAM-D) score >= 18 at baseline; (3) aged between 13 and 18 years old, right-handed, with some reading ability; (4) subjects or their guardians sign an informed consent form. Additional inclusion criteria for the MECT treatment group were (1) there are obvious suicide, self-injury behavior, accompanied by psychotic symptoms; (2) currently in their first episode of depressive symptoms and not having received antidepressant or mood-stabilizing drugs prior to this treatment; or (2) on a fixed dose of antidepressant and/or mood-stabilizing drugs for >=6 weeks at the time of enrollment, with no planned changes to their treatment regimen in the near future. Inclusion criteria for the healthy control group were (1) age between 13-18 years old and right-handed, and (2) good health, with normal physical and laboratory tests prior to participation in the program.
Exclusion criteria
Exclusion criteria: (1) combined with other mental disorders; (2) combined with serious somatic diseases, nervous system diseases, and mental retardation; (3) unable to cooperate or uncooperative with the assessment; (4) unable to undergo MRI scanning for other reasons, such as metal implants in the body, etc. Additional exclusion criteria for the MECT treatment group were: (1) history of brain disease, brain injury, seizures, and other neurological disorders; (2) history of serious systemic diseases such as cardiovascular, respiratory, immune, hepatic, and renal dysfunction; and (3) physical therapy such as ECT, MECT, transcranial magnetic stimulation therapy, transcranial direct current therapy, and systemic psychotherapy in the previous 6 months.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Clinical symptoms;Multimodal MRI;Hematological index;Cognitive function; | — |
Countries
China
Contacts
Public ContactXia Lei
Chaohu Hospital of Anhui Medical University
Outcome results
None listed