Tourniquet associated hypertension
Conditions
Interventions
Esketamine Group (S Group):After anesthesia induction (tracheal catheter fixation), esketamine was injected intravenously at a rate of 0.3mg?kg-1?h-1 until the tourniquet was released.
Dexmedetomidine group (Group D):After the end of anesthesia induction, dexmedetomidine was pumped for 20 minutes at a load dose of 0.5ug?kg-1, and then at an administration rate of 0.4ug?kg-1?h-1 unti
Normal saline group (N group):The same volume of sodium chloride injection pump is calculated according to the actual body mass of the patient.
Sponsors
Affiliated Hospital of Qingdao University
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: Patients who underwent knee surgery under general anesthesia combined with nerve block with pneumatic tourniquet in our hospital from October 2024 to October 2025 (total knee replacement, knee unicondylar surface replacement, arthroscopic anterior cruciate ligament reconstruction, and knee double compartment replacement) are expected to sign informed consent. They were randomly divided into esketamine group (group S), dexmedetomidine group (group D) and saline group (group N) according to random number table method. American Society of Anesthesiologists (ASA) Grade I to III, ages 18 to 80 years.
Exclusion criteria
Exclusion criteria: Exclusion criteria: 1 Patients who did not receive formal antihypertensive therapy or whose blood pressure was poorly controlled, i.e., systolic blood pressure = 160 mmHg or = 90 mmHg, and/or diastolic blood pressure =100 mmHg; 2 The history of ropivacaine allergy, puncture site infection, serious coagulation disorders and other puncture contraindications; 3 Patients with severe chronic diseases such as systemic chronic pain disease and severe dysfunction of liver and kidney function. 4 The patient had severe sinus bradycardia (< 50 beats/min)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of tourniquet-related hypertension;Incidence of tourniquet shock; | — |
Secondary
| Measure | Time frame |
|---|---|
| Hemodynamic mean;blood gas analysis;The amount of medication to be used when the tourniquet is applied; | — |
Countries
China
Contacts
Public ContactMa Chao
Affiliated Hospital of Qingdao University
Outcome results
None listed