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The mechanism of RNA binding protein RCAN1.1 promoting neuronal mitochondrial fission in acute ischemic stroke

The mechanism of RNA binding protein RCAN1.1 targeting and regulating Miro2 to promote neuronal mitochondrial fission in acute ischemic stroke

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR2500096396
Enrollment
Unknown
Registered
2025-01-22
Start date
2023-07-10
Completion date
Unknown
Last updated
2025-01-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Acute ischemic stroke

Interventions

Healthy control group:None

Sponsors

Qilu Hospital of Shandong University
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to No maximum

Inclusion criteria

Inclusion criteria: Both the healthy control group and the ischemic stroke group were recruited during the diagnosis and treatment Healthy control group inclusion criteria: (1) Han nationality; (2) Be over 18 years old; (3) The person or his/her legal representative signs an informed consent form. Ischemic stroke group inclusion criteria: (1) Han nationality, the patient is over 18 years old; (2) Diagnosed with ischemic stroke; (3) The person or his/her legal representative signs an informed consent form.

Exclusion criteria

Exclusion criteria: Exclusion Criteria for Healthy Controls Group: (1) History of cardiovascular and cerebrovascular diseases; (2) Surgery within the past 3 months; (3) Previous history of bleeding disorders; (4) malignant tumors; (5) infectious diseases; (6) Pregnant and lactating women. Exclusion Criteria for Ischemic Stroke Group: (1) Recurrent episodes or strokes lasting more than 24 hours; (2) TIA and cerebral hemorrhage; (3) Severe heart, lung or kidney damage; (4) malignant tumors; (5) Surgery in the past 3 months and history of bleeding disorders; (6) infectious diseases; (7) Pregnant and lactating women.

Design outcomes

Primary

MeasureTime frame
Plasma RCAN1 protein level ;

Secondary

MeasureTime frame
RCAN1.1L mRNA in plasma;Magnetic resonance data;

Countries

Chian

Contacts

Public ContactYan Yun

Qilu Hospital of Shandong University

yanyun@email.sdu.edu.cn+86 159 6633 5429

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026