None listed
Conditions
Interventions
Dexmedetomidine group:Continuous infusion of dexmedetomidine for 24 hours, starting within 10 minutes before the surgery and continuing until the first postoperative day.
Control group:None
Sponsors
the Affiliated Drum Tower Hospital of Nanjing University Medical School
Eligibility
Sex/Gender
All
Age
18 Years to 85 Years
Inclusion criteria
Inclusion criteria: 1. Patients undergoing PD/PPPD surgery in pancreatic surgery; 2. Age >= 18 years; 3. ASA classification of 1-3; 4. Able to clearly understand and voluntarily participate in the study.
Exclusion criteria
Exclusion criteria: 1. Drug users, alcohol-dependent individuals, or those abusing opioid medications; 2. Known adrenal insufficiency or long-term corticosteroid therapy; 3. Individuals with severe cognitive impairments or mental disorders who cannot comply with assessments; 4. Preoperative serum amylase or lipase levels above the normal upper limit; 5. A history of chronic pain and long-term use of analgesics and/or sedatives preoperatively; 6. Patients with second-degree or higher atrioventricular block or those requiring oral ß-blockers postoperatively; 7. Subjects and guardians who refuse to participate in this study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of severe pain within 72 hours post-operation;VAS score at 72 hours postoperatively; | — |
Secondary
| Measure | Time frame |
|---|---|
| differences of plasma surgical stress and inflammatory markers;time to bowel movement;incidence of post-pancreatectomy acute pancreatitis,clinically relevant pancreatic fistula,infections and delayed gastric emptying, ;length of hospital stay after operation;Incidence of severe resting pain (resting VAS = 4) from 72 hours post-operation to discharge;Time and incidence of the first rescue analgesia;Cumulative consumption of opioids postoperatively;Incidence of chronic pain postoperatively; | — |
Countries
China
Contacts
Public ContactYudong Qiu
Nanjing Drum Tower Hospital Clinical College of Nanjing University of Chinese Medicine/Nanjing Drum Tower Hospital
Outcome results
None listed