periodontitis
Conditions
Interventions
SRP+Er:YAG+ LPCGF:SRP+Er:YAG+CGF treat root surface
SRP+Er:YAG group:SRP+Er:YAG treat root surface
SRP+ LPCGF:SRP+hyaluronic acid gel treat root surface
SRP :SRP treat root surface
Sponsors
Fujian Medical University Affiliated Stomatological Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria of isolated teeth with periodontal disease: 1 Age 18~70 years old; 2 No other oral diseases and systemic diseases; 3 No antibiotics and other hormone drugs taken within 3 months; 4 Stage III ~ IV periodontitis teeth (according to the periodontal classification criteria in 2018: the most serious attachment loss of adjacent surface >= 5 mm, imaging shows that alveolar bone resorption to more than 1/2 of the root; 5 There are indications for tooth extraction, and there are no contraindications for tooth extraction; No scaling and root surface leveling in recent half a year; Root surface integrity, no caries, no obvious cracks, no vertical root fracture, the number of dental calculus on each root surface is basically equal. Venous blood is from volunteers, undergraduate or graduate healthy population, no systemic history, no medication history Gingiva derived from crown lengthening patients without systemic disease.
Exclusion criteria
Exclusion criteria: Exclusion criteria of isolated teeth: scaling and root planing in recent half a year; incomplete root surface, caries, cracks, vertical root fracture and root resorption. Venous and gingival sources Exclusion criteria: Patients with systemic history
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| roughness;Adhesion and proliferation and migration of GMSCCs on root surface;Detection of osteogenic differentiation ability of GMSCCs on root slices; | — |
Secondary
| Measure | Time frame |
|---|---|
| Calcium and phosphorus content of root surface;cementum retention;histological examination of root slice;Effects on blood cell attachment and fibrin network formation on root surface; | — |
Countries
china
Contacts
Public ContactXiaoHong Wu
Fujian Medical University Affiliated Stomatological Hospital
Outcome results
None listed