Chronic thromboembolic pulmonary hypertension
Conditions
Interventions
Gold Standard:The current diagnostic algorithm typically includes an initial assessment, hemodynamic assessment, and imaging tests. The initial evaluation includes a detailed examination of the patien
Index test:Based on DDR, the optimal cutoff value of pulmonary blood flow signal for the diagnosis of CTEPH was established, and a method for analyzing the amount of lung blood flow perfusion was esta
Sponsors
Peking Union Medical College Hospital, Chinese Academy of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Age>=18 years 2. Patients with confirmed or suspected CTEPH: a. Confirmed CTEPH: meets the diagnostic criteria for CTEPH recommended by the 2015 European Society of Cardiology (ESC)/European Respiratory Society (ERS) guidelines: • Adequate, regular anticoagulation therapy >=3 months • Radiographic evidence (including: pulmonary ventilation/perfusion imaging, transcatheter pulmonary angiography, CT pulmonary angiography) confirming the presence of pulmonary artery thromboembolism • Haemodynamics consistent with diagnostic criteria for pulmonary hypertension (i.e., mean pulmonary arterial pressure (mPAP) of >=25 mmHg at rest, at sea level, right heart catheterization, and pulmonary movement Pulmonary arterial wedge pressure (PAWP) =20 mmHg, or pulmonary artery systolic blood pressure estimated by cardiac ultrasound >35 mmHg • Has a history of lower extremity deep vein thrombosis or pulmonary embolism, or at least one of the following risk factors Heart rate>=100 beats per minute Oxygen saturation < 95% Swelling of the lower extremities Taking drugs that cause blood clotting disorders (such as glucocorticoids, birth control pills, etc.) Hypercoagulable state (e.g., thrombophilia, malignancy, nephrotic syndrome, postoperative, traumatic, etc.) 3. Agree and be able to complete functional dynamic digital radiography (DDR), right heart catheterization, and transcatheter pulmonary angiography 4. Sign the informed consent form
Exclusion criteria
Exclusion criteria: 1. Patients who have not signed the informed consent form; 2. Patients with severe renal insufficiency (eGFR<30 mL/min/1.73m^2); 3. Patients who are allergic to iodine contrast medium or have a history of severe allergic reaction; 4. Combined with other serious lung diseases that may significantly affect the assessment of pulmonary blood flow, including but not limited to: severe interstitial lung disease, advanced emphysema, history of lung surgery (such as lobectomy); 5. Other diseases that cause pulmonary artery stenosis, including but not limited to: congenital pulmonary artery stenosis, Takayasu Takayasu arteritis involving pulmonary arteries, pulmonary artery sarcoma, fibromediastinitis; 6. Pregnant or lactating women; 7. Patients with expected survival of less than 6 months.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| DDR signal intensity ratio; | — |
Countries
China
Contacts
Public ContactShen Jianzhong;Wang Yun
Peking Union Medical College Hospital, Chinese Academy of Medical Sciences
Outcome results
None listed