carpal tunnel syndrome
Conditions
Interventions
Loop Carpal Tunnel Release Group:Undergoing Ultrasound-guided Loop Carpal Tunnel Release surgery
Open Carpal Tunnel Release Group:Undergoing Open Carpal Tunnel Release surgery
Sponsors
Sun Yat-sen Memorial Hospital, Sun Yat-sen University
Eligibility
Sex/Gender
All
Age
40 Years to 70 Years
Inclusion criteria
Inclusion criteria: (1)Aged 40–70 years; (2)Exhibiting typical symptoms of carpal tunnel syndrome (e.g., finger numbness, tingling, weakness, or pain; symptoms aggravated by repetitive or sustained gripping; worsening symptoms at night) and typical signs (e.g., sensory deficits or weakness in the hand; positive Tinel's sign or Phalen's test for the median nerve); (3)Meeting the criteria for typical or possible carpal tunnel syndrome based on the Katz hand diagram diagnostic standards; (4)Electromyography indicating abnormalities of the median nerve; (5)Ultrasound revealing thickening of the transverse carpal ligament and compression of the median nerve; (6)Ineffective conservative treatments (e.g., immobilization, oral NSAIDs, local corticosteroid injections) for more than 3 months; (7)Able to understand the study process, willing to participate in the study, capable of completing a 2-year postoperative follow-up, and providing informed consent; (8)Normal or near-normal coagulation function tests (based on the normal range values of each research center's laboratory): a. Prothrombin time (PT) prolonged by =3 seconds and b. Activated partial thromboplastin time (APTT) prolonged by =10 seconds.
Exclusion criteria
Exclusion criteria: (1)Ultrasound findings indicating bifurcation of the median nerve or a persistent median artery at the carpal tunnel entry, or compression of the carpal tunnel caused by cysts, tumors, or fracture fragments; (2)Systemic infection or localized infection at the surgical site; (3)Previous surgery for carpal tunnel syndrome on the affected side being treated; (4)Patients with uncontrolled epilepsy, cervical radiculopathy, or diabetic peripheral neuropathy; (5)Allergy to local anesthetics; (6)Inability to complete questionnaire assessments due to language or cognitive impairments; (7)Pregnant or breastfeeding women; (8)Severe cardiac disease or conditions rendering the patient unable to tolerate surgery, including but not limited to: Fatal arrhythmias or high-grade atrioventricular block, Unstable angina, Clinically significant valvular heart disease, Electrocardiographic evidence of transmural myocardial infarction, Uncontrolled hypertension; (9)Any other condition deemed by the researcher to make the patient unsuitable for participation in the study, such as coexisting diseases or conditions that may interfere with study participation or pose a serious medical risk to the subject (e.g., psychiatric disorders, uncontrolled heart disease, hypertension, active or uncontrolled infections).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Boston carpal tunnel questionnaire symptom severity scale scores;Boston carpal tunnel questionnaire functional status scale scores; | — |
Secondary
| Measure | Time frame |
|---|---|
| Quick Disabilities of the Arm, Shoulder and Hand scores;12-Item Short-Form Health Survey (SF-12);Grip strength;Pinch strength;Ultrasound measurement of the cross-sectional area of the median nerve at the proximal inlet of the carpal tunnel;Visual analogue scale scores;Hospitalization costs;Length of stay; | — |
Countries
China
Contacts
Public ContactHou Jingyi
Sun Yat-sen Memorial Hospital, Sun Yat-sen University
Outcome results
None listed