Preeclampsia
Conditions
Interventions
Healthy pregnancy control:None
Mild preeclampsia :None
Severe preeclampsia :None
Sponsors
Women's Hospital School of Medicine Zhejiang University
Eligibility
Sex/Gender
Female
Age
18 Years to 40 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria for normal pregnant women and patients: Ages between 18 and 40 years, gestational age between 20 and 34 weeks. Singleton pregnancies, with signed informed consent. Patient inclusion criteria are based on the ‘Guidelines for the Diagnosis and Treatment of Hypertensive Disorders in Pregnancy (2020)’. The definition of preeclampsia is a blood pressure greater than 140/90 mm Hg, along with the presence of 300 mg of protein in a 24-hour urine sample. The definition of severe preeclampsia includes: systolic blood pressure greater than 160 mm Hg or diastolic blood pressure greater than 110 mm Hg, with more than 5 g of protein excreted in a 24-hour urine sample, and one or more of the following conditions: intrauterine growth restriction (IUGR) less than the 10th percentile, persistent neurological symptoms (headache, visual disturbances), HELLP syndrome: hemolysis, elevated liver enzymes (greater than twice the normal level), oliguria (less than 500 mL in 24 hours), serum creatinine greater than 1.0 mg/dL, and low platelet count (below 100,000 cells/µL).
Exclusion criteria
Exclusion criteria: Exclusion criteria include pregnant women with multiple fetuses, as well as those with severe extra-genital conditions, including diabetes, kidney disease, and cardiovascular diseases.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Urinary protein; | — |
Countries
China
Contacts
Public ContactHong Wen
Women's Hospital School of Medicine Zhejiang University
Outcome results
None listed