Autoimmune hepatitis
Conditions
Interventions
AIH:None
Sponsors
Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology
Eligibility
Sex/Gender
All
Age
No minimum to 17 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria: (1) By searching through our hospital's electronic medical record system, a total of 3,280 pediatric cases diagnosed with "autoimmune hepatitis, liver insufficiency, liver cirrhosis, acute icteric hepatitis, cholestatic liver disease, non-icteric hepatitis, acute liver failure, cystic fibrosis, sclerosing cholangitis, obstructive cholangitis, and elevated transaminase levels" were selected from the pediatric infectious digestive ward between January 1, 2013, and December 31, 2022. (2) From the aforementioned pool, a total of 222 patients who met any one of the conditions in "1" and any one of the conditions in "2" were included in the study:1. Evidence of liver injury: (a) Alanine aminotransferase (ALT) activity >= 2 × ULN (upper limit of normal), (b) total bilirubin (TB) >= 2 × ULN, (c) evidence of hepatomegaly or liver cirrhosis; 2.Clinical features of the patients consistent with autoimmune hepatitis (AIH): (a) significantly elevated autoimmune markers and/or total serum protein levels, (b) histological features characteristic of AIH, (c) significant response to corticosteroid therapy.
Exclusion criteria
Exclusion criteria: Exclusion criteria:Cases without blood test results, incomplete data, and those that do not meet the diagnostic criteria for autoimmune-like hepatitis.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Liver function;Immunologic function;Autoantibody; | — |
Countries
China
Contacts
Public ContactSainan Shu
Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology
Outcome results
None listed