None listed
Conditions
Interventions
A group:Lidocaine for sciatic nerve block preoperatively and liposomal bupivacaine for sciatic nerve block postoperatively
B group:Ropivacaine for sciatic nerve block preoperatively
Sponsors
Shanghai Jiao Tong University Affiliated Sixth people’s hospital
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: (1) Age 18-70 years old; (2) Patients undergoing foot and ankle surgery (such as open reduction and internal fixation for fractures, bunion correction, and other procedures lasting less than 2 hours) (3) American Society of Anesthesiologists (ASA) grade I to II. (4) Voluntary and signed informed consent. (5) Subjects with a working phone.
Exclusion criteria
Exclusion criteria: (1) History of allergy to the study drugs used in this study (2) Body mass index (BMI) >40 kg/m2; (3) Combined with neuromuscular diseases (such as muscle weakness, Parkinson's disease, etc.); (4) Suffered from mental illness (such as Alzheimer's disease, epilepsy, etc.) ; (5) Preoperative limb sensory impairment ; (6) Local skin infection or coagulation disorder; (7) Suffering from severe systemic diseases or liver and kidney dysfunction; (8) Patients who refuse to participate in the study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Postoperative strength of toes or ankle at 3 hours;Postoperative visual analogue scale(VAS) at 24 hours; | — |
Secondary
| Measure | Time frame |
|---|---|
| Consumption of opioids (e.g., sufentanil) ;Satisfaction and quality of recovery within 24 hours after surgery(QoR-15);Incidence of postoperative adverse events (such as nausea and vomiting, urinary retention, adverse reactions to local anesthetics, etc.).;Analgesic rescue;Postoperative strength of toes or ankle at 0,6,12,24 hours;The proportion of participants in rehabilitation treatment within 24 hours and 48 hours after surgery;Postoperative visual analogue scale(VAS) at 0,3,6,12, 72 hours;Time to onset of preoperative nerve block;The onset, resolution and duration of sensory and motor blockade;Proportion of patients who are pain-free and without salvage medication at each time;The percentage patients who are not using opioids after surgery; | — |
Countries
China
Contacts
Public ContactAizhong Wang
Shanghai Jiao Tong University Affiliated Sixth people’s hospital
Outcome results
None listed