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Effects of dexmedetomidine before abdominal closure on emergence agitation and stress response in aged patients undergoing laparoscopic colorectal cancer surgery

Effects of dexmedetomidine before abdominal closure on emergence agitation and stress response in aged patients undergoing laparoscopic colorectal cancer surgery

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2500096247
Enrollment
Unknown
Registered
2025-01-21
Start date
2021-03-04
Completion date
Unknown
Last updated
2025-01-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Emergence Agitation

Interventions

D1:Use 0.5 ug/kg dexmedetomidine
D2:Use 0.75 ug/kg dexmedetomidine
D3:Use 0.3 ug/kg dexmedetomidine
C:Normal saline control

Sponsors

Yangpu Hospital,Tongji University School of Medicine,Shanghai
Lead Sponsor

Eligibility

Sex/Gender
All
Age
60 Years to 80 Years

Inclusion criteria

Inclusion criteria: 1.Patients with confirmed colorectal cancer who underwent laparoscopic radical resection of colorectal cancer and >= 60 years of age 2.ASA I-III 3.Signed informed consent

Exclusion criteria

Exclusion criteria: 1.?°-? AVB ; 2.Sinus bradycardia and Atropine test(-); 3.Cerebral infarction with sequelae; 4.Patients with psychiatric disorders; 5.Severe abnormal liver and kidney function; 6.Drug addicts

Design outcomes

Primary

MeasureTime frame
Cortisol;Richmond Agitation—Sedation Scale,RASS;—

Secondary

MeasureTime frame
Heart Rate;Blood Pressure;—

Countries

China

Contacts

Public ContactZhoulin Chen

Yangpu Hospital,Tongji University School of Medicine,Shanghai

bai2002com@aliyun.com+86 21 6569 0520

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026