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Metabolomics-based exploration of markers of RA activity period

Analysis of plasma, serum and urinary metabolites in the normal population and in patients with rheumatoid inflammatory joints

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR2500096245
Enrollment
Unknown
Registered
2025-01-21
Start date
2025-01-31
Completion date
Unknown
Last updated
2025-01-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Rheumatoid arthritis

Interventions

RA remission period:none
RA active period:none
healthy control:none

Sponsors

Guanghua Hospital Affiliated to Shanghai University of Traditional Chinese Medicine,
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 80 Years

Inclusion criteria

Inclusion criteria: Inclusion criteria for RA group: 1. Agree to participate in this study and sign the informed consent form; 2. The age is between 18 and 80 years old; 3. According to the classification standard of American College of Rheumatology (ACR)/European League against Rheumatism (EULAR) in 2010, the patient was definitely diagnosed as RA. Inclusion criteria for normal control group: 1. agreed to participate in this study and signed an informed consent form; 2. aged between 18 and 80 years old; 3. did not meet the 2010 American College of Rheumatology (ACR)/European League Against Rheumatism (the European League Against Rheumatism, the EULAR) RA classification criteria for healthy people.

Exclusion criteria

Exclusion criteria: Exclusion criteria for RA: 1. Patients with serious diseases such as heart, liver, brain, kidney and hematopoietic system (ALT or AST is more than 3 times higher than the normal upper limit, and GFR of chronic kidney disease above stage III is less than 30 ml/min); 2, infectious diseases, hyperuricemia > 6 months, gout, thyroid disease, urinary tract infection, the existence of malignant tumor or medical history; 3, combined with other rheumatic diseases such as systemic lupus erythematosus, Sjogren's syndrome, ankylosing spondylitis, scleroderma, etc. 4. Patients with remission period less than 6 months and taking hormones in the past six months; 5. Patients who cannot cooperate or complete sample collection. Exclusion criteria for normal healthy controls: same as those for RA patients.

Design outcomes

Primary

MeasureTime frame
differential metabolites;

Secondary

MeasureTime frame
Differential Lipoproteins;

Countries

China

Contacts

Public ContactLianbo Xiao/ Rui Wang

Guanghua Clinical Medical College, Guanghua Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai, China.

wr1997tcm@163.com+86 21 6280 5833

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026