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Alfentanil combined with dexmedetomidine for painless conscious sedation in outpatient gastroscopy in obese patients

Alfentanil combined with dexmedetomidine for painless conscious sedation in outpatient gastroscopy in obese patients

Status
Active, not recruiting
Phases
Early Phase 1
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2500096208
Enrollment
Unknown
Registered
2025-01-20
Start date
2024-09-06
Completion date
Unknown
Last updated
2025-01-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Anesthesia for obese patients

Interventions

experimental group:Dexmedetomidine 0.6 µg/kg was pumped intravenously for 10 min, and 6 µg/kg alfentanil (Yichang Renfu Pharmaceutical) was injected intravenously for conscious sedation.
control subjects:Intravenous 6 µg/kg alfentanil, propofol/etomidate mixture 2-3 mg/kg

Sponsors

Department of Anesthesiology, Shiyan People's Hospital (People's Hospital Affiliated to Hubei Medical College)
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 65 Years

Inclusion criteria

Inclusion criteria: Inclusion criteria: obese patients who underwent painless gastroscopy in Shiyan People's Hospital from September 2024 to October 2024, aged 18-65 years, ASA classification ?-?, BMI = 28kg/m2, airway assessment ( Mallampati classification) classification ?-? were selected.

Exclusion criteria

Exclusion criteria: Exclusion criteria: exclude patients with serious lesions of heart, liver, kidney and other organs; patients with combined fever (temperature = 38.5?) or upper respiratory tract infection; patients who are allergic to or have contraindications to benzodiazepines, opioids, propofol and its components; patients who are suspected of having a difficult airway; patients who have bradycardia (HR<50 beats/min), atrioventricular (AV) block of the second degree or above.

Design outcomes

Primary

MeasureTime frame
Incidence of intraoperative respiratory depression;

Secondary

MeasureTime frame
cholesterol;pulse rate;

Countries

China

Contacts

Public ContactRui Xue

Department of Anesthesiology, Shiyan People's Hospital (People's Hospital Affiliated to Hubei Medical College)

xuerui1106@126.com+86 134 7616 7178

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026