mammary cancer
Conditions
Interventions
Sufentanil group:Sufentanil 2 ug / kg + halobiprofen ester 100mg + palonosetron 0.25mg=100ml
Esketamine group:Eesketamine 2.5mg / kg + flurbiprofen ester 100mg + palonosetron 0.25mg=100ml
Esketamine and dexmedetomidine group:Eesketamine 2.5mg / kg + dexmedetomidine 2 ug / kg + hallobiprofen ester 100mg + paronosetron 0.25mg=100ml
Sponsors
Hainan Affiliated Hospital of Hainan Medical University
Eligibility
Sex/Gender
Female
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: (1)> 18 years; (2) American Society of Anesthesiologists (American Society of Anesthesiologists, ASA) grade I-II; (3) not pregnant; (4) diagnosis of breast cancer and proposed radical breast cancer.
Exclusion criteria
Exclusion criteria: (1) body mass index (body mass index, BMI)>30 kg/m²; (2) History of angina pectoris or myocardial infarction in the past 6 months; (3) Unwell-controlled or untreated hypertension (resting systolic / diastolic blood pressure> 180 / 100 mmHg); (4) Untreated or undertreated hyperthyroidism; (5) Liver and renal insufficiency; (6) Neuropsychiatric diseases; (7) Long-term alcoholism; (8) Long-term use of sedative, hypnotic, analgesic and antipsychotic drugs; (9) Heart rate (heart rate, HR) <50 times / min or with III degree atrioventricular block; (10) Know to be allergic to test drugs such as dexmedetomidine and (or) esketamine; (11) Change of the operation mode during the operation; (12) Loss of perioperative
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| anxiety-depression; | — |
Secondary
| Measure | Time frame |
|---|---|
| selep quality ;pain;calm; | — |
Countries
China
Contacts
Public ContactDuozhi Wu
Hainan Affiliated Hospital of Hainan Medical University
Outcome results
None listed