Temporal Lobe Epilepsy
Conditions
Interventions
Treatment group:Short time electrical stimulation using SEEG electrodes
Sponsors
Xuanwu Hospital Capital Medical University
Eligibility
Sex/Gender
All
Age
10 Years to 50 Years
Inclusion criteria
Inclusion criteria: 1. Patients aged 10-50 years; for participants under the age of 18, they must agree to comply with all protocol requirements, and their parents or legal guardians must be willing to provide informed consent, approved by the Institutional Review Board (IRB)/Independent Ethics Committee (IEC)/Human Research Ethics Committee (HREC), before any study-related procedures are undertaken. 2. Patients with temporal lobe epilepsy that has not been effectively controlled despite more than two years of standard treatment with antiepileptic drugs. 3. Patients who have been diagnosed with medial temporal lobe epilepsy based on multidisciplinary discussions involving neurology, neurosurgery, and radiology departments. 4. Patients scheduled to undergo stereoelectroencephalography (SEEG) implantation with electrodes covering medial temporal structures and the retrosplenial cortex (RSC) region. 5. Comprehensive preoperative evaluation has been completed, and contraindications for the corresponding surgical procedure have been excluded. 6. Patients capable of understanding the study procedures. 7. Patients who provide informed consent and sign the informed consent form.
Exclusion criteria
Exclusion criteria: 1. Serious neurological or mental illness; 2. Persons who are seriously dependent on drugs, alcohol or illicit drugs; 3. Can not cooperate with the completion of preoperative non-invasive evaluation examination or preoperative evaluation; 4. Patients with other surgery-related contraindications; 5. Local infection or active systemic infection at the intended surgical approach site; 6. Those who cannot receive electrode implantation due to the need for treatment or examination of other diseases; 7. Those who refuse to participate in the experiment; 8. Patients with temporal lobe epilepsy without SEEG records 9. Those deemed unsuitable by the researcher;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Hippocampal Spike Discharge Count;Hippocampal High-Frequency Oscillation Count;Length of Hippocampal Seizure Discharge Duration; | — |
Secondary
| Measure | Time frame |
|---|---|
| Intensity of Hippocampal Evoked Potentials;Safety of Electrical Stimulation of the Retrosplenial Cortex ; | — |
Countries
China
Contacts
Public ContactWang Yihe
Department of Neurosurgery of Xuanwu Hospital Capital Medical University
Outcome results
None listed