None
Conditions
Interventions
case series:none
Sponsors
Qilu Hospital of Shandong University (Qingdao)
Eligibility
Sex/Gender
All
Age
18 Years to 100 Years
Inclusion criteria
Inclusion criteria: Aged 18 years or older, regardless of gender; Successfully resuscitated after cardiopulmonary resuscitation (including chest compressions, defibrillation, etc.) and in the acute recovery phase (usually within 24 hours); Willing to participate in the study and sign the informed consent form; Meeting the indications for hypothermia therapy; Clinically stable at the time of entering the study and able to tolerate the intervention measures of the study; Able to undergo gut microbiota sampling (e.g., stool samples) and without severe gastrointestinal bleeding or contraindications for surgery.
Exclusion criteria
Exclusion criteria: Severe comorbidities or end-stage diseases: such as end-stage liver disease, renal failure, terminal cancer, etc., with a short life expectancy or those unable to undergo effective treatment; Pregnant or breastfeeding women; Severe cardiovascular and cerebrovascular diseases: such as cardiogenic shock, severe arrhythmias, cerebrovascular accidents, etc., that prevent the patient from tolerating hypothermia therapy after cardiopulmonary resuscitation; Gut dysfunction: including severe acute intestinal injury, intestinal obstruction, or other diseases affecting normal bowel function; Immunosuppressive states: such as patients on immunosuppressive drugs or those with obvious immune dysfunction (e.g., HIV infection, organ transplant recipients, etc.); Failure to meet the indications for hypothermia therapy; Patients or their family members who have not signed the informed consent form or who refuse to participate in the study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Changes in the composition of intestinal flora; | — |
Secondary
| Measure | Time frame |
|---|---|
| Heart rate variability;intestinal barrier function;Inflammatory response marker;GCS score;ICU Mortality Rate ;28-Day Mortality Rate;SOFA Score and APACHE II Score; | — |
Countries
China
Contacts
Public ContactZhiyang Wu
Qilu Hospital of Shandong University (Qingdao)
Outcome results
None listed